The Smith Lab studies protein structure and dynamics using a combination of computer simulation and nuclear magnetic resonance (NMR) spectroscopy. We are particularly interested in optimizing the dynamics of computationally designed proteins and understanding how mutations allosterically affect the functions of natural proteins.

Colin Smith is a member of the Chemistry department at Wesleyan University. He is also affiliated with the Molecular Biophysics program, the Molecular Biology and Biochemistry department, and the College of Integrative Sciences.

We are located on the first floor of the Hall-Atwater science building. The wet lab is in room 128, dry lab in 134, and Colin’s office in room 130. The location of these rooms and free street parking is shown on this map.

Our research is supported by a National Science Foundation CAREER Award, the National Institutes of Health, NSF ACCESS/XSEDE supercomputer time, and the Rosetta Commons.


Smith Lab
Wesleyan University
Hall-Atwater Laboratories
52 Lawn Avenue
Middletown, CT 06459